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Updated: Apr 30, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Alveolar Bone Augmentation Using Octacalcium Phosphate and Collagen Composite with Custom-Made Titanium Mesh: A Case

Tadashi Kawai¹, Atsushi Ogawa¹, Yunosuke Ikeda¹

¹Division of Oral and Maxillofacial Surgery, Department of Reconstructive Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, Morioka, Iwate, Japan.

The American Journal of Case Reports

|September 18, 2025

Summary

Octacalcium phosphate (OCP) and OCP collagen composite (OCP/Col) show promise for bone regeneration. This case report details successful extensive alveolar bone augmentation using OCP/Col and a titanium mesh for dental implants.

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Last Updated: Apr 30, 2026

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Published on: November 16, 2018

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3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects

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Published on: August 4, 2020

Area of Science:

Biomaterials Science
Regenerative Medicine
Oral and Maxillofacial Surgery

Background:

Autologous bone grafts are superior for bone regeneration but challenging for extensive augmentation.
Octacalcium phosphate (OCP) and its collagen composite (OCP/Col) demonstrate enhanced bone substitute capabilities.
Alveolar bone defects often require advanced augmentation techniques for successful dental implant restoration.

Purpose of the Study:

To report the first clinical application of OCP/Col combined with a custom titanium mesh for extensive alveolar bone augmentation.
To demonstrate the efficacy of this combination in reconstructing maxillary anterior alveolar bone defects.
To restore occlusion and aesthetics using dental implants following bone augmentation.

Main Methods:

A custom titanium mesh was designed based on preoperative simulations for ideal alveolar morphology.
Extensive alveolar bone augmentation was performed using OCP/Col and the custom titanium mesh.
Dental implants were placed six months post-augmentation, followed by prosthesis insertion.

Main Results:

Ideal alveolar morphology was reconstructed six months after bone augmentation with OCP/Col and titanium mesh.
Successful placement of dental implants and restoration of occlusion and aesthetics were achieved.
The patient experienced significant improvement in quality of life post-treatment.

Conclusions:

OCP/Col combined with a custom titanium mesh is effective for reconstructing extensive alveolar bone defects.
This approach offers a viable solution for challenging cases requiring significant bone augmentation in the maxillary anterior region.
The successful outcome highlights the potential of OCP/Col as a bone substitute in combination with rigid fixation for complex reconstructive procedures.