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Future directions in combating outbreaks at CEPI Centralized Laboratory Network
Ali Azizi1, Gathoni Kamuyu2, Peter Spencer2
1Laboratory Research and Innovations, Coalition for Epidemic Preparedness Innovations (CEPI), Washington, DC, USA.
Human Vaccines & Immunotherapeutics
|September 18, 2025
Summary
The CEPI Centralized Laboratory Network (CLN) meeting standardized immunological assays for emerging diseases like SARS-CoV-2. Enhancements improve preparedness for future outbreaks, including Disease X, through better technology and partnerships.
Area of Science:
- Global Health
- Immunology
- Infectious Disease Research
Background:
- The Coalition for Epidemic Preparedness Innovations (CEPI) Centralized Laboratory Network (CLN) convened experts to address challenges in assay development for emerging infectious diseases.
- Standardization of immunological assays is critical for rapid response during global health emergencies.
Purpose of the Study:
- To review achievements in standardizing immunological assays for emerging diseases, particularly SARS-CoV-2.
- To identify and address challenges in assay development, validation, and technology transfer.
- To align network goals with CEPI's 100-Day Mission for rapid assay development against Disease X.
Main Methods:
- Gathering 67 experts from 27 global institutions, including key collaborators like WHO, BARDA, and the Gates Foundation.
- Facilitating discussions on reagent access, protocol harmonization, and logistical/quality barriers.
- Focusing on preparedness, sustainability, rapid testing, high-throughput technologies, and inter-facility communication.
Main Results:
- Showcased achievements in standardizing immunological assays for emerging diseases.
- Identified key challenges in assay development, validation, and technology transfer.
- Highlighted strategies for preparedness, including rapid testing and partnerships for the 100-Day Mission.
Conclusions:
- Post-meeting actions have improved quality systems, high-throughput assays, and technology transfer strategies.
- Enhanced partnerships and adaptability strengthen the network's response to global health emergencies.
- The CEPI-CLN is crucial for advancing standardized immunological assays for rare and emerging diseases.
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