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Future directions in combating outbreaks at CEPI Centralized Laboratory Network.

Ali Azizi1, Gathoni Kamuyu2, Peter Spencer2

  • 1Laboratory Research and Innovations, Coalition for Epidemic Preparedness Innovations (CEPI), Washington, DC, USA.

Human Vaccines & Immunotherapeutics
|September 18, 2025
PubMed
Summary

The CEPI Centralized Laboratory Network (CLN) meeting standardized immunological assays for emerging diseases like SARS-CoV-2. Enhancements improve preparedness for future outbreaks, including Disease X, through better technology and partnerships.

Keywords:
CEPIVaccinesassaysimmunogenicityoutbreak

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Area of Science:

  • Global Health
  • Immunology
  • Infectious Disease Research

Background:

  • The Coalition for Epidemic Preparedness Innovations (CEPI) Centralized Laboratory Network (CLN) convened experts to address challenges in assay development for emerging infectious diseases.
  • Standardization of immunological assays is critical for rapid response during global health emergencies.

Purpose of the Study:

  • To review achievements in standardizing immunological assays for emerging diseases, particularly SARS-CoV-2.
  • To identify and address challenges in assay development, validation, and technology transfer.
  • To align network goals with CEPI's 100-Day Mission for rapid assay development against Disease X.

Main Methods:

  • Gathering 67 experts from 27 global institutions, including key collaborators like WHO, BARDA, and the Gates Foundation.
  • Facilitating discussions on reagent access, protocol harmonization, and logistical/quality barriers.
  • Focusing on preparedness, sustainability, rapid testing, high-throughput technologies, and inter-facility communication.

Main Results:

  • Showcased achievements in standardizing immunological assays for emerging diseases.
  • Identified key challenges in assay development, validation, and technology transfer.
  • Highlighted strategies for preparedness, including rapid testing and partnerships for the 100-Day Mission.

Conclusions:

  • Post-meeting actions have improved quality systems, high-throughput assays, and technology transfer strategies.
  • Enhanced partnerships and adaptability strengthen the network's response to global health emergencies.
  • The CEPI-CLN is crucial for advancing standardized immunological assays for rare and emerging diseases.