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Long-term survival in a male patient with Müllerian adenocarcinoma of the pelvis: a 15-year case report

  • 0Unità Operativa di Oncologia Integrata, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy.
Frontiers in Oncology +

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September 18, 2025

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September 18, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

This case report details a rare Müllerian adenocarcinoma in a male patient, successfully treated with multimodal therapy including surgery, chemotherapy, and radiotherapy. The treatment resulted in exceptional long-term survival and good quality of life.

Area Of Science

  • Oncology
  • Rare Cancers
  • Genitourinary Oncology

Background

  • Müllerian adenocarcinoma is a rare, aggressive cancer typically affecting women, originating from the uterus or ovary.
  • Extragenital and male cases are exceptionally rare, often presenting with a poor prognosis.
  • This report focuses on a unique case in a male patient with pelvic Müllerian adenocarcinoma.

Purpose Of The Study

  • To describe a unique clinical case of Müllerian adenocarcinoma in a male patient.
  • To highlight the successful application of multimodal therapy in a rare cancer presentation.
  • To report on exceptional long-term survival and quality of life in this patient.

Main Methods

  • The patient received a combination of cytoreductive surgery, chemotherapy (modeled after ovarian cancer treatment), and radiotherapy.
  • The treatment approach was multimodal, integrating various therapeutic modalities.
  • Long-term follow-up was conducted to assess outcomes.

Main Results

  • The patient achieved exceptional survival of nearly 15 years post-diagnosis.
  • A good quality of life was maintained throughout the extensive treatment period.
  • This represents the first reported case of pelvic Müllerian adenocarcinoma in a male treated with multimodal therapy achieving long-term survival.

Conclusions

  • Multimodal therapy, including chemotherapy for ovarian cancer, radiotherapy, and cytoreductive surgery, can lead to long-term survival in rare male Müllerian adenocarcinoma cases.
  • Treatment protocols for ovarian cancer may be applicable to Müllerian adenocarcinoma in men due to shared embryological origins.
  • This case suggests a potential therapeutic strategy for this rare malignancy.

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