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Related Experiment Video

Updated: Jul 7, 2026

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation
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Lead-Tutor: An Open-Access Educational Resource for Deep Brain Stimulation Electrode Localizations.

Savir Madan1, Lauren A Hart1, Ningfei Li2

  • 1Center for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.

Aperture Neuro
|September 18, 2025
PubMed
Summary

Lead-Tutor is a new open-access educational resource for Deep Brain Stimulation (DBS) electrode localization. It combines imaging data with a software tool to help train researchers, promoting open science and reproducibility in DBS research.

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Area of Science:

  • Neurosurgery
  • Medical Imaging
  • Computational Neuroscience

Background:

  • Deep Brain Stimulation (DBS) is a neurosurgical treatment for brain disorders.
  • Accurate reconstruction of implanted electrode placement is critical for optimizing DBS therapy.
  • Existing DBS electrode reconstruction tools often require expert input and lack open-access training datasets.

Purpose of the Study:

  • To introduce Lead-Tutor, an open-access educational resource for Deep Brain Stimulation (DBS) electrode localization.
  • To provide a combined imaging dataset and software tool for self-teaching electrode localization skills.
  • To promote open science and enhance the training of new researchers in the DBS field.

Main Methods:

  • Developed Lead-Tutor, integrating an anonymized DBS imaging dataset with the Lead-DBS software pipeline.
  • Included pre- and post-operative MRI and CT scans from ten patients with DBS implants.
  • Provided a practice environment for users to improve DBS electrode localization accuracy.

Main Results:

  • Created an open-access educational resource combining a dataset and software tool for DBS electrode localization training.
  • Facilitated self-teaching and skill enhancement for researchers new to the DBS field.
  • Supported open science principles by providing accessible data and tools.

Conclusions:

  • Lead-Tutor serves as a comprehensive resource for training DBS researchers.
  • The resource promotes enhanced reproducibility in DBS research through standardized training.
  • Lead-Tutor has potential applications for improving clinical practice and patient outcomes in DBS therapy.