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Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
Published on: July 24, 2016
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Oropouche virus disrupts neurodevelopment and is vertically transmitted.
Kellie Jurado1, Carl Bannerman1, Drake Philip1
1University of Pennsylvania.
Research Square
|September 18, 2025
Summary
Oropouche virus (OROV) can now cause congenital infections and neurodevelopmental issues. This study shows OROV infects fetal brain cells, causing microcephaly-like conditions and highlighting the need for OROV monitoring.
Area of Science:
- Virology
- Neuroscience
- Developmental Biology
Background:
- Oropouche virus (OROV) traditionally caused mild illness.
- Recent OROV strains are linked to congenital infections and neurodevelopmental problems.
- This necessitates studying OROV's role as a congenital pathogen.
Purpose of the Study:
- To investigate OROV's vertical transmission capabilities.
- To determine OROV's impact on fetal neurodevelopment.
- To compare OROV's neurotropic potential with Zika virus (ZIKV).
Main Methods:
- Utilized human forebrain organoids to model congenital OROV infection.
- Assessed OROV infection and pathology in neural progenitor cells.
- Employed a murine model to study vertical transmission and fetal tissue infection.
- Investigated OROV's antagonism of innate immune signaling pathways.
Main Results:
- OROV is vertically transmitted, infecting fetal tissues in a mouse model.
- OROV robustly infects human neural progenitor cells within organoids.
- OROV induced a microcephaly-like phenotype in human forebrain organoids.
- OROV demonstrated a greater capacity for infection and pathology than ZIKV.
- OROV's heightened pathogenesis is partly due to antagonizing innate immunity.
Conclusions:
- OROV can be vertically transmitted, posing a risk to fetal development.
- OROV exhibits a significant capacity for causing neurodevelopmental disruption, including microcephaly.
- Findings highlight OROV as a re-emerging threat requiring vigilant monitoring for congenital infections.
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