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Biomaterials strategy for promoting palatal wound healing.
Wen Tong1, Junxin Ren1, Xinyi Yao1
1Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Frontiers in Bioengineering and Biotechnology
|September 18, 2025
Summary
This review explores biomaterials for palatal wound healing, addressing limitations of current treatments. Biomaterials show therapeutic potential for orofacial function restoration and severe wound management.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Oral and Maxillofacial Surgery
Background:
- Palatal wounds impair crucial orofacial functions and pose risks.
- Current surgical treatments face limitations like infection and poor healing.
- Biomaterial research offers advanced solutions for palatal wound repair.
Purpose of the Study:
- To review biomaterials for palatal wound healing.
- To summarize advances in preclinical and clinical studies.
- To highlight the therapeutic potential of biomaterials.
Main Methods:
- Comprehensive literature review of biomaterials for palatal wounds.
- Analysis of acellular dermal matrix, platelet-rich derivatives, amniotic membrane, growth factors, hyaluronic acid, collagen, hydrogels, and nanofibers.
- Discussion of wound healing mechanisms.
Main Results:
- Various biomaterials show promise in preclinical and clinical studies.
- Biomaterials can address challenges like tissue defects and inflammation.
- Specific materials like ADM, PRF, PRP, and hydrogels are discussed.
Conclusions:
- Biomaterials represent a significant advancement in palatal wound management.
- These materials offer therapeutic potential for restoring orofacial functions.
- Further research can optimize biomaterial application in tissue engineering for palatal defects.
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