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Related Concept Videos

Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

642
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
642
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

802
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
802

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Related Experiment Video

Updated: Jan 17, 2026

Endoscopic Vacuum Therapy for the Treatment of Anastomotic Leakage after Total Gastrectomy with Esophagojejunostomy
04:05

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Published on: August 22, 2025

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Margin clearance and post-procedure ablation decrease recurrence risk in endoscopic mucosal resections for

Phoenix D Bell1, Vivek Kaul2, Krystle M Bittner2

  • 1Department of Pathology, Cleveland Clinic, Cleveland, OH, USA.

Histopathology
|September 18, 2025
PubMed
Summary
This summary is machine-generated.

Post-procedure ablation significantly reduces recurrence risk for Barrett's-related esophageal neoplasia after endoscopic mucosal resection (EMR). Lack of ablation increases recurrence, especially for high-grade dysplasia and carcinoma.

Keywords:
adenocarcinomaendoscopic mucosal resectionoesophagusprognostic factors

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Area of Science:

  • Gastroenterology
  • Oncology
  • Pathology

Background:

  • Endoscopic mucosal resection (EMR) is a standard treatment for Barrett's-associated esophageal dysplasia and early cancer.
  • Disease recurrence after EMR is a significant clinical concern.
  • Identifying factors predicting recurrence is crucial for optimizing patient management.

Purpose of the Study:

  • To analyze clinical and histopathologic factors associated with local disease recurrence following EMR for Barrett's-related esophageal neoplasia.
  • To assess the impact of post-procedure ablation on recurrence rates.

Main Methods:

  • Retrospective analysis of 290 EMR specimens from 129 patients with glandular neoplasia.
  • Inclusion of patient demographics, lesion characteristics, margin status, and post-procedure treatments.
  • Statistical analysis of 227 eligible cases to identify predictors of local recurrence.

Main Results:

  • Adenocarcinoma was the highest-grade lesion in 42% of specimens.
  • Recurrence of same or worse disease was observed in 46% of cases.
  • Lack of post-procedure ablation was linked to increased recurrence risk for high-grade dysplasia and carcinoma.
  • Poor differentiation and positive margin status also increased recurrence risk for carcinoma.

Conclusions:

  • Differentiation, margin status, and post-EMR ablation are key determinants of local recurrence risk in Barrett's-related adenocarcinoma.
  • Tumor budding and invasion depth did not significantly impact recurrence in this cohort.
  • Post-procedure ablation is critical for reducing recurrence rates.