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Chronic Postsurgical Pain-induced Postoperative Anxiety Risk
Biopsychosocial Science and Medicine
|September 18, 2025
Summary
Chronic postsurgical pain (CPSP) independently increases the risk of developing postoperative anxiety. Early identification and management of CPSP are crucial for improving patient outcomes after major surgery.
Area of Science:
- Anesthesiology
- Pain Medicine
- Psychiatry
Background:
- Chronic postsurgical pain (CPSP) is a common complication after major surgery.
- Postoperative anxiety significantly impacts patient recovery and quality of life.
Purpose of the Study:
- To investigate the independent association between CPSP and the risk of developing postoperative anxiety.
- To evaluate the clinical relevance of CPSP as a predictor of anxiety.
Main Methods:
- Retrospective cohort study using Taiwan's National Health Insurance Research Database (NHIRD).
- Inclusion of 134,726 patients undergoing major surgery (2004-2020).
- Propensity score matching (PSM) and multivariate Cox proportional hazards models were utilized.
Main Results:
- Patients with CPSP exhibited a significantly higher risk of postoperative anxiety (aHR = 1.48; 95% CI = 1.43-1.53) post-matching.
- The association between CPSP and anxiety remained robust across sensitivity analyses.
- CPSP was identified as an independent predictor of postoperative anxiety.
Conclusions:
- CPSP is a significant and independent predictor of postoperative anxiety.
- Targeted management of CPSP is essential to mitigate psychological distress.
- Integrating CPSP assessment into perioperative care can enhance patient outcomes.
Keywords:
= American Society of Aneshesiologists= National Health Insurance Research Databaseanxietychronic postsurgical painincidence ratepredictiverisk factorsMore Related Videos
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