Gastrointestinal Environment Intelligent-Responsive Nanozyme for the Treatment of Multidrug-Resistant Helicobacter
Ke Wang1, Shiru Sun1, Xiaobing Tang1
1School of Medical Engineering, Haojing College of Shaanxi University of Science & Technology, Xianyang, Shaanxi, 712046, P. R. China.
Abstract:
Helicobacter pylori is a pathogen that can withstand the pH levels in the stomach and cause gastric infections. It is widely recognized as a major risk factor for gastric diseases, and its eradication could effectively treat peptic ulcers and gastritis, and reduce the mortality rate of gastric cancer. However, the antibiotic combination therapies typically used to eradicate H. pylori can disrupt the gut microbiota. Therefore, this study presents a gastrointestinal environment intelligent-responsive nanozyme (CeOSL) for treatment of multidrug-resistant H. pylori infections and regulation of inflammation. The oxidase-like activity of CeOSL is activated in the gastric juice and mucus, which generates superoxide radicals that eradicate H. pylori. Furthermore, CeOSL can scavenge reactive oxygen species to alleviate inflammation in the gastric epithelium with no significant effect on symbiotic microbiota, which addresses the pathological conditions associated with H. pylori infections. This pH-modulated nanozyme approach provides a safer and more effective strategy for treatment of H. pylori infections.
Related Concept Videos
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
Peptic Ulcer Disease IV: Management
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...


