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Construction of Customizable Wrinkle-Patterned Hydrogel/Fibrous Membrane Composites for Wound Healing
Yuping Dong1, Xueyan Li1, Jinlong Gao1
1Innovation Center for Textile Science and Technology, College of Textiles, Donghua University, Shanghai, 201620, China.
Small (Weinheim an Der Bergstrasse, Germany)
|September 18, 2025
Summary
This study presents a novel wrinkled hydrogel/fibrous membrane composite for burn wound healing. The advanced dressing enhances mechanical properties and promotes stem cell migration for improved tissue repair.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Wound Healing
Background:
- Hydrogels are promising for burn wound dressings due to high water content.
- Existing hydrogels have limitations in stretchability and wound healing efficacy.
- Developing advanced wound dressings is crucial for effective burn treatment.
Purpose of the Study:
- To fabricate customizable wrinkle-patterned hydrogel/fibrous membrane (HFM) composites.
- To enhance mechanical properties and wound healing efficacy of hydrogel dressings.
- To investigate the potential of gradient immobilization of stromal-cell-derived factor 1α (SDF1α) for burn wound repair.
Main Methods:
- Fabrication of HFM composites using mask-assisted photo-crosslinking and substrate pre-stretching.
- Incorporation of tannic acid (TA) to improve interfacial adhesion.
- Gradient immobilization of SDF1α and in vitro/in vivo assessments for wound healing.
Main Results:
- The HFM composites exhibited superior mechanical properties (>400% elongation, 1.2 MPa tensile strength) and shape recovery.
- Gradient SDF1α immobilization directed stem cell migration in vitro.
- In vivo studies showed reduced inflammation and enhanced deep second-degree burn wound repair in rats.
Conclusions:
- The customizable wrinkled HFM composite demonstrates significant potential for burn wound repair.
- Synergistic effects of wrinkle patterns and TA enhance mechanical performance.
- SDF1α gradient immobilization effectively promotes wound healing by reducing inflammation and directing cell migration.
