Related Experiment Video
Updated: Jan 17, 2026
From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding
Published on: March 24, 2018
Octahedral iodide Mo6 cluster complex bearing thiosulfate ligands: a dual chemotherapeutic and radiodynamic agent for
Tatiana N Pozmogova1,2, Margarita V Vegner1, Yuri A Vorotinkov1
1Nikolaev Institute of Inorganic Chemistry SB RAS, 3 Acad. Lavrentiev ave., 630090 Novosibirsk, Russia. shtopy@niic.nsc.ru.
Abstract:
Cancer treatment faces significant challenges due to tumor heterogeneity, drug resistance, and the limited efficacy of single-agent therapies, driving the search for novel therapeutic approaches. The water-soluble molybdenum cluster complex Na5Cs3[{Mo6I8}(S2O3)6]·3H2O, developed in this study, represents a unique compound that combines a strong chemotherapeutic effect, achieved through the controlled release of sulfur-containing gas-signaling molecules (H2S and SO2) during hydrolysis, with a radiodynamic effect, enabled by the ability of the cluster to generate singlet oxygen (1O2) under X-rays. The results of in vitro experiments confirmed significant cytostatic effects on cancer cells, while in vivo studies using Nu/J mice xenografted with HeLa tumors showed substantial tumor growth inhibition when the cluster was administered subcutaneously in combination with X-ray irradiation. Overall, the dual functionality of the cluster, along with the slow release and prolonged retention of the complex in tumor tissues, makes it a highly promising candidate for advanced cancer treatment strategies, particularly when integrated with conventional radiotherapy.
More Related Videos
12:30Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
08:47Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
Published on: March 6, 2019
Related Concept Videos
02:26Preparation and Reactions of Sulfides
02:34Structural Isomerism
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
02:51Metal-Ligand Bonds
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
03:35Hybridization of Atomic Orbitals II
02:52Stereoisomerism
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
02:27Predicting Molecular Geometry