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Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Basophil Activation Test for Allergy Diagnosis
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Allergen immunotherapy: effective on lung function?

Edoardo Cavaglià1,2, Maurizio Marogna3, Giovanni Paoletti1,2

  • 1Department of Biomedical Sciences, Humanitas University, Pieve Emanuele.

Current Opinion in Allergy and Clinical Immunology
|September 18, 2025
PubMed
Summary
This summary is machine-generated.

Allergen immunotherapy (AIT) shows potential for sustained asthma benefits and may improve lung function, but robust long-term evidence is still limited. Further research is needed to confirm its role in altering asthma progression.

Keywords:
allergen immunotherapyasthmadisease modificationlung functionsublingual immunotherapy

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Area of Science:

  • Pulmonology
  • Immunology
  • Allergy

Background:

  • Asthma management is evolving towards disease-modifying strategies targeting type 2 inflammation.
  • Allergen immunotherapy (AIT) is a key intervention for allergic diseases.
  • Understanding AIT's long-term impact on asthma progression is crucial.

Purpose of the Study:

  • To review the evidence on allergen immunotherapy's effects on lung function in asthma.
  • To focus on the long-term outcomes of AIT in asthma patients.
  • To assess AIT's potential role in disease modification for asthma.

Main Methods:

  • Systematic review of observational and randomized controlled studies.
  • Analysis of clinical benefits, asthma control, exacerbation rates, and lung function.
  • Inclusion of recent real-world prospective studies.

Main Results:

  • Sublingual immunotherapy (SLIT) may offer sustained clinical benefits and positive effects on lung function.
  • Consistent improvements in asthma control and reduced exacerbations are observed.
  • Robust evidence for long-term lung function preservation is limited; some studies suggest allergen-independent benefits on FEV1.

Conclusions:

  • AIT is established as a disease-modifying treatment for allergic conditions.
  • AIT's capacity to prevent or slow lung function decline in asthma requires further investigation.
  • Future research should focus on longitudinal spirometry data across various allergens and populations to clarify AIT's role in asthma progression.