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Deciphering the Role of Long Non-coding RNAs in Neural Differentiation and Reprogramming
Ziran Xu1, Nianhong Lu1, Jiangyuan Wang1
1Department of Clinical Laboratory, Lequn Branch, The First Hospital of Jilin University, Changchun, Jilin, China.
Stem Cell Reviews and Reports
|September 18, 2025
Summary
Long non-coding RNAs (lncRNAs) are vital for neural development and function. This review explores their roles in stem cell differentiation and neurological diseases, highlighting therapeutic potential.
Area of Science:
- Neuroscience
- Molecular Biology
- Genetics
Background:
- Long non-coding RNAs (lncRNAs) are key regulators in the central nervous system.
- They influence neural development through transcriptional, epigenetic, and post-transcriptional modulation.
Purpose of the Study:
- To review recent advances in lncRNA regulation of neural differentiation.
- To summarize the role of lncRNAs in neurological diseases and their therapeutic potential.
Main Methods:
- Literature review of studies on lncRNAs in neural stem cell differentiation.
- Analysis of lncRNA involvement in neurogenesis and neurological disorders.
- Discussion of lncRNA-mediated regulatory networks.
Main Results:
- lncRNAs regulate stem cell differentiation by interacting with transcription factors, chromatin regulators, and microRNAs.
- Dysregulated lncRNAs are implicated in Alzheimer's disease, Parkinson's disease, and glioblastoma.
- lncRNAs influence neuroinflammation, synaptic dysfunction, and tumor progression.
Conclusions:
- lncRNAs are critical for neural development and disease.
- lncRNAs show promise as diagnostic biomarkers and therapeutic targets for neurological disorders.
- Targeting lncRNAs may offer novel strategies for regenerative medicine and precision neuro-oncology.
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