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Updated: Jan 17, 2026
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Characterization and Functional Prediction of Bacteria in Ovarian Tissues
Published on: October 23, 2021
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Oral Bacterial and Fungal Microbiome and Subsequent Risk for Pancreatic Cancer.
Yixuan Meng1,2, Feng Wu1,2, Soyoung Kwak1,2
1Department of Population Health, NYU Grossman School of Medicine, New York, New York.
JAMA Oncology
|September 18, 2025
Summary
Oral bacteria and fungi are linked to pancreatic cancer development. Specific oral pathogens and a microbial risk score indicate increased risk, suggesting oral microbiota could be biomarkers for early detection and personalized prevention.
Area of Science:
- Microbiome research
- Oncology
- Epidemiology
Background:
- The oral microbiome's role in pancreatic cancer is suggested but evidence is limited.
- Current research primarily uses 16S amplicon sequencing and small retrospective studies.
Purpose of the Study:
- To investigate the association between the oral bacterial and fungal microbiome and subsequent pancreatic cancer development.
Main Methods:
- A large cohort study utilizing data from two epidemiological cohorts.
- Oral microbiome analysis via whole-genome shotgun sequencing (bacteria) and ITS sequencing (fungi).
- Statistical analysis including logistic regression and ANCOM-BC2 to identify associated taxa and develop a microbial risk score (MRS).
Main Results:
- Three specific oral bacterial periodontal pathogens (P. gingivalis, E. nodatum, P. micra) were associated with increased pancreatic cancer risk.
- A wide-range analysis identified 8 bacteria associated with decreased risk and 13 with increased risk.
- The genus Candida was linked to higher pancreatic cancer risk, and the developed MRS showed a significant association with increased risk (OR, 3.44).
Conclusions:
- Oral bacteria and fungi are significant risk factors for pancreatic cancer.
- The oral microbiome shows potential as a biomarker for identifying individuals at high risk of pancreatic cancer.
- These findings may contribute to personalized prevention strategies for pancreatic cancer.
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