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Advances in sorbent peritoneal dialysis technologies: A narrative review
Susan Bríd McGrath1, Pauline Kosalka2, Marjorie W Foo3
1Nephrology Department, London Health Sciences Center, London, Ontario, Canada.
Summary
Sorbent peritoneal dialysis (SPD) devices show promise for kidney disease treatment, with several models demonstrating effective waste removal and fluid management. Further human trials are needed to establish their role in dialysis therapy.
Area of Science:
- Nephrology
- Biomedical Engineering
- Medical Devices
Background:
- Sorbent peritoneal dialysis (SPD) regenerates dialysate using sorbent layers, offering a potential alternative to conventional dialysis methods.
- Several SPD devices, including AWAK (Viva Kompact), Carry Life, WEAKID, ViWAK, and Renart-PD, have been developed and studied.
Purpose of the Study:
- To review and compare the design, dialysis clearance, and ultrafiltration (UF) capacity of five SPD devices based on published literature.
- To assess the current status and potential of these devices in treating kidney disease.
Main Methods:
- Literature review of published studies (human trials, animal studies, in vitro data) on five SPD devices.
- Analysis of reported data on dialysis clearance (solute removal) and ultrafiltration (fluid removal) capacity.
Main Results:
- All reviewed devices demonstrated dialysis clearance capabilities.
- WEAKID and Carry Life PD showed high solute gradients; Viva Kompact and Renart-PD reported reduced serum waste markers.
- ViWAK effectively removed creatinine and other solutes. Carry Life UF and Viva Kompact showed significant UF capacity, with improved efficiency per gram of glucose used.
Conclusions:
- SPD devices exhibit potential for effective waste removal and fluid management in dialysis.
- While promising, many devices lack comprehensive human trial data, particularly regarding UF capacity.
- Large-scale human studies are essential to determine the future clinical role of these SPD devices in peritoneal dialysis.
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