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Modified Cellulose for Intestinal Health.

Minhui Xu1,2, Jinfeng Zhao2, Hanyu Wang1

  • 1Bamboo Resource Conservation and Utilization Key Laboratory of Sichuan Province, Leshan Normal University, Leshan, Sichuan 614000, China.

Journal of Agricultural and Food Chemistry
|September 18, 2025
PubMed
Summary

Modified cellulose offers a promising, sustainable solution for bowel disorders, addressing limitations of current treatments. Its versatile applications include drug delivery, gut health regulation, and immune modulation for improved intestinal therapies.

Keywords:
intestinal healthmodification methodmodified cellulosenanocellulose

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Area of Science:

  • Biomaterials Science
  • Gastroenterology
  • Polymer Chemistry

Background:

  • Increasing global prevalence of intestinal diseases necessitates advanced therapeutic approaches.
  • Conventional treatments for bowel disorders present challenges including side effects, cost, and neurotoxicity.
  • Cellulose, a biocompatible and sustainable polymer, shows potential for therapeutic applications in intestinal health.

Purpose of the Study:

  • To review recent advancements in modified cellulose for managing intestinal diseases.
  • To analyze structure-function relationships of cellulose derivatives and their therapeutic mechanisms.
  • To explore future directions, including artificial intelligence in material design for cellulose-based therapies.

Main Methods:

  • Systematic review of literature on modified cellulose in intestinal disease management.
  • Analysis of physical, chemical, and biological modification methods for cellulose.
  • Evaluation of therapeutic mechanisms, including drug/probiotic delivery, microbiota regulation, barrier function, immune modulation, and toxin adsorption.

Main Results:

  • Modified cellulose demonstrates diverse therapeutic potential through various functionalization strategies.
  • Key mechanisms include targeted delivery, gut microbiota modulation, intestinal barrier enhancement, immune response regulation, and toxin binding.
  • Structure-property relationships are crucial for optimizing cellulose derivatives for specific intestinal applications.

Conclusions:

  • Modified cellulose presents a viable, safe, and effective platform for novel intestinal therapies.
  • Further research and development, aided by AI, can accelerate the clinical translation of cellulose-based treatments.
  • This review provides a comprehensive overview for developing next-generation therapies for bowel disorders.