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Published on: September 6, 2017
Donor-Derived Clonal Haematopoiesis after Allogeneic Stem-Cell Transplantation: A Case Report
Adrian Schwarzer1, Christian Späth1, Thomas Neumann1
1Department of Internal Medicine C, Haematology and Oncology, Stem Cell Transplantation, Palliative Care, University Medicine Greifswald, Greifswald, Germany.
Introduction:
The accidental transmission of both malignant and non-malignant haematological diseases through allogeneic haematopoietic stem-cell transplantation (alloSCT) has been documented. Next-generation sequencing enables the detection of a broad spectrum of mutations associated with myeloid and other disorders.
Case Presentations:
We report two cases of donor-derived myeloid clonal haematopoiesis (M-CHIP) following alloSCT. In one case, donor-derived CHIP was stabilized through donor-lymphocyte infusions administered in response to declining donor chimerism.
Conclusion:
The transfer of M-CHIP by alloSCT is not uncommon. The long-term relevance of these findings for patients and donors should be the subject of larger prospective trials. Furthermore, the transplantation of CHIP is not uncommon and presents significant medical and ethical challenges.
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