Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outcomes of Patients with RET Fusion-Positive Non-Small Cell Lung Cancer Treated with First-Line Non-Molecularly Targeted Therapies: A Real-World Benchmark in Europe from the RECALIB-RET Study.

Advances in therapy·2026
Same author

Transportability Analyses in Comparative Effectiveness Research: A Conceptual Framework and Methodological Principles Endorsed by the International Society for Pharmacoepidemiology.

Pharmacoepidemiology and drug safety·2026
Same author

Insights into adherence to cladribine tablets in the real world in multiple countries: results from patient support programs.

Therapeutic advances in neurological disorders·2026
Same author

Curriculum in Pharmacoepidemiology Training Programs: A Cross-Sectional Study to Assess Educational Needs and Alignment With Core Competencies.

Pharmacoepidemiology and drug safety·2026
Same author

Evaluating Data Quality by Proxy: Can We Evaluate All Dimensions of the European Medicines Agency Data Quality Framework for Registry-Based Post-Authorization Safety Studies?

Pharmacoepidemiology and drug safety·2026
Same author

Summary of Research: Pregnancy and Infant Outcomes in Multiple Sclerosis: Findings from the Global MAPLE-MS Pharmacovigilance Program.

Neurology and therapy·2026

Related Experiment Video

Updated: Jan 17, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

87.6K

A Systematic Review of Algorithms for Identifying Pediatric Neurodevelopmental Outcomes.

Sandra Lopez-Leon1,2, Xuerong Wen3, Sneha Gaitonde2

  • 1Quantitative Safety & Epidemiology, Novartis Pharmaceuticals, East Hanover, New Jersey, USA.

Pharmacoepidemiology and Drug Safety
|September 18, 2025
PubMed
Summary

This study reviewed algorithms for pediatric neurodevelopmental outcomes (NDO) in electronic health data. It recommends using single outcomes and validated algorithms for accurate epidemiological estimates, especially for autism spectrum disorder and ADHD.

Keywords:
attention‐deficit hyperactivity disorderautismneurodevelopmentalpharmacoepidemiologypregnancyreal‐world evidencevalidation

More Related Videos

A Novel Experimental and Analytical Approach to the Multimodal Neural Decoding of Intent During Social Interaction in Freely-behaving Human Infants
11:14

A Novel Experimental and Analytical Approach to the Multimodal Neural Decoding of Intent During Social Interaction in Freely-behaving Human Infants

Published on: October 4, 2015

11.4K
Measuring the Functional Abilities of Children Aged 3-6 Years Old with Observational Methods and Computer Tools
11:29

Measuring the Functional Abilities of Children Aged 3-6 Years Old with Observational Methods and Computer Tools

Published on: June 20, 2020

9.7K

Related Experiment Videos

Last Updated: Jan 17, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

87.6K
A Novel Experimental and Analytical Approach to the Multimodal Neural Decoding of Intent During Social Interaction in Freely-behaving Human Infants
11:14

A Novel Experimental and Analytical Approach to the Multimodal Neural Decoding of Intent During Social Interaction in Freely-behaving Human Infants

Published on: October 4, 2015

11.4K
Measuring the Functional Abilities of Children Aged 3-6 Years Old with Observational Methods and Computer Tools
11:29

Measuring the Functional Abilities of Children Aged 3-6 Years Old with Observational Methods and Computer Tools

Published on: June 20, 2020

9.7K

Area of Science:

  • Pediatric Health Research
  • Epidemiology
  • Health Informatics

Background:

  • Investigating pediatric neurodevelopmental outcomes (NDO) using secondary data presents challenges due to inconsistent definitions and coding.
  • Electronic healthcare data offers a valuable resource, but requires standardized algorithms for reliable NDO assessment.

Purpose of the Study:

  • To systematically review and identify algorithms used for defining NDO in studies utilizing electronic healthcare data.
  • To understand the methodologies employed in defining NDO for pediatric populations in research.

Main Methods:

  • A systematic literature review was conducted for studies from January 1, 2010, to March 10, 2025.
  • Search terms focused on NDO algorithms, routinely collected healthcare data, and pediatric populations.
  • Two independent reviewers screened studies, with a third reviewer resolving discrepancies; descriptive statistics were used.

Main Results:

  • 156 publications using NDO algorithms were included; 18 studies validated their outcomes.
  • Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) were the most studied NDOs.
  • Most studies focused on ASD (65.6%) and ADHD (45.9%), often as single or composite outcomes.

Conclusions:

  • Presenting multiple single NDOs is recommended over composite outcomes for clarity and precision.
  • Validated algorithms, particularly single-code diagnoses in Nordic data, show high predictive value; US data may require more complex algorithms.
  • Clearly defining the timing of NDO assessment is crucial for valid epidemiological estimates.