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Related Experiment Video

Updated: May 7, 2026

Transcriptome Profiling of In-Vivo Produced Bovine Pre-implantation Embryos Using Two-color Microarray Platform
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Aging-associated transcriptomic changes in the bovine endometrium.

Denis Karani Wanjiru1, Yvan Bienvenu Niyonzima1, Yoichi Mizukami2

  • 1Joint Faculty of Veterinary Medicine, Yamaguchi University, Yoshida 1677-1, Yamaguchi-shi, Yamaguchi-ken 753-8515, Japan.

Gene
|September 18, 2025
PubMed
Summary

Aging significantly alters gene expression in the bovine endometrium, impacting fertility. This study identified key differentially expressed genes (DEGs) and pathways affected by age in cattle reproductive tissues.

Keywords:
AgingBovine EndometriumCellular senescenceG-protein-coupled receptorJapanese Black cattleRNA-seqRuminants

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Area of Science:

  • Reproductive biology
  • Genomics
  • Molecular biology

Background:

  • Endometrial function is crucial for fertility.
  • Aging negatively impacts endometrial activity, but underlying mechanisms in cattle are not fully understood.

Purpose of the Study:

  • To identify age-related differentially expressed genes (DEGs) in the bovine endometrium.
  • To elucidate the molecular pathways affected by aging in cattle reproductive tissues.

Main Methods:

  • RNA sequencing was employed to compare gene expression in the endometrium of aged multiparous cows and young nulliparous heifers.
  • Metascape and Ingenuity Pathway Analysis (IPA) were used to analyze differentially expressed genes (DEGs) and associated signaling pathways.

Main Results:

  • A significant number of DEGs were identified in both intercaruncular (ICAR) and caruncular (CAR) endometrial regions of aged cows.
  • Enriched pathways in ICAR included cell growth, lipid biosynthesis, and G-protein-coupled receptor signaling.
  • Enriched pathways in CAR involved collagen formation and epithelial differentiation, with implications for wound healing.

Conclusions:

  • Aging induces substantial changes in gene expression and signaling pathways within the bovine endometrium.
  • These age-related molecular alterations provide insights into impaired fertility in older cattle.
  • Identification of specific DEGs and pathways offers potential targets for future reproductive interventions.