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Flavonoid intake and kidney stones: An exposome-based cross-sectional study
Yuan Gong1, Yuanyuan Yang1, Lintao Miao1
1Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
None:
The present study aimed to evaluate the relationships between total, subgroup and individual dietary flavonoid intake and the risk of kidney stones. Data from the National Health and Nutrition Examination Survey and the Food and Nutrient Database for Dietary Studies were analyzed. A total of 9033 participants without kidney stones and 985 participants with kidney stones were included. A dose-response relationship curve suggested a J-shaped relationship (P for nonlinearity < .001) between flavanone intake and kidney stone risk (nadir point: 32.23 mg/d, OR: 0.70, 95% CI: 0.58-0.84). Naringenin (a type of flavanones) was negatively associated with kidney stone risk. Hesperetin was associated with kidney stone risk in a J-shaped manner. These findings suggest that flavanone consumption may be beneficial for individuals with elevated kidney stone risk.
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