Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jan 17, 2026

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications
05:33

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications

Published on: November 20, 2019

9.2K

Microfluidics in biomanufacturing process development.

Federico Moreno-Sibaja1, Da Zou1, Sha Liu1

  • 1School of Chemical Engineering, Faculty of Sciences, Engineering and Technology, The University of Adelaide, Adelaide, SA, 5005, Australia.

Biotechnology Advances
|September 18, 2025
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vertebral BMSC-EVs under estrogen deficiency drive senescence-related mitochondrial dysfunction in endplate chondrocytes via MRPL1 mRNA delivery.

Experimental & molecular medicine·2026
Same author

Minimal Peptide Surfactants for Long-Lasting Nanoemulsions via Noncovalent Interfacial Interactions.

ACS applied materials & interfaces·2026
Same author

Optimizing the use of adsorbent resin for the amelioration of smoke tainted wine.

Food chemistry: X·2026
Same author

Curvature-degradation coupling drives cellular functions and osteointegration in additively manufactured biodegradable Zn-Mg scaffolds.

Biomaterials·2026
Same author

Dual-stiffness nanoparticles for compartment-specific drug delivery in stroke.

Nature communications·2026
Same author

Correction: Rapid, Scalable, and Cost-Effective Manufacturing of Uniform Non-Enveloped, Tag-Free Virus-Like Particles.

Current protocols·2026
Same journal

Enzymes for CO<sub>2</sub> fixation: Discovery, engineering, and applications.

Biotechnology advances·2026
Same journal

Technological advances in extrachromosomal circular DNA detection.

Biotechnology advances·2026
Same journal

Codon compression and novel codon creation for multiplex non-canonical amino acid incorporation.

Biotechnology advances·2026
Same journal

Toward next-generation biosurfactants: Engineering rhamnolipid production from safe chassis design to scalable bioprocessing.

Biotechnology advances·2026
Same journal

Advances and challenges in alternative proteins: From biotechnology to sustainable food production.

Biotechnology advances·2026
Same journal

Recent advances in the microbial production of L-arginine and its derivatives using engineering Corynebacterium glutamicum and Escherichia coli.

Biotechnology advances·2026
See all related articles

Microfluidic systems offer rapid, cost-effective biomanufacturing development by enabling high-throughput experiments and enhanced control. This technology streamlines both upstream and downstream bioprocessing, paving the way for optimized scale-up.

Area of Science:

  • Biotechnology
  • Chemical Engineering
  • Process Development

Background:

  • Biomanufacturing demand for high-value products is increasing.
  • Scale-down systems are crucial for early-stage bioprocess development.
  • Microfluidics offers dynamic, high-throughput experimentation with reduced volumes.

Purpose of the Study:

  • To review microfluidic fundamentals for biomanufacturing.
  • To discuss microfluidic applications in upstream and downstream bioprocessing.
  • To present challenges and future perspectives in microfluidic biomanufacturing.

Main Methods:

  • Review of microfluidic systems and their integration in bioprocessing.
  • Discussion of sensor and automation integration for data acquisition.
Keywords:
Biological processingDeviceHigh-throughputMicrofluidicProcess developmentScale upUnit operation

More Related Videos

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods
07:51

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

Published on: December 23, 2013

7.8K
Development of New Therapeutic Applications Using Microfluidics
08:56

Development of New Therapeutic Applications Using Microfluidics

Published on: October 1, 2007

5.7K

Related Experiment Videos

Last Updated: Jan 17, 2026

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications
05:33

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications

Published on: November 20, 2019

9.2K
High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods
07:51

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

Published on: December 23, 2013

7.8K
Development of New Therapeutic Applications Using Microfluidics
08:56

Development of New Therapeutic Applications Using Microfluidics

Published on: October 1, 2007

5.7K
  • Analysis of microfluidic applications across the bioprocessing workflow.

    • Main Results:

    • Microfluidics enables rapid, cost-effective bioprocess development.
    • Applications span strain development, cell growth, lysis, and purification.
    • Integration of sensors and automation is key for optimization and scale-up.

    Conclusions:

    • Microfluidic systems are powerful tools for optimizing biomanufacturing processes.
    • Challenges include fabrication, automation, and AI integration.
    • Future perspectives focus on advancing these areas for improved bioprocess development and scale-up.