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Personalised exercise-rehabilitation for people with multiple long-term conditions (PERFORM): a randomised
Rachael A Evans1,2, Sharon A Simpson3, James R Manifield1,2
1Respiratory Sciences, University of Leicester, Leicester, UK.
BMJ Open
|September 18, 2025
Summary
The PERFORM program, a personalized exercise rehabilitation for multiple long-term conditions (MLTCs), is feasible and acceptable. This supports further trials to assess its clinical effectiveness for patients with complex health needs.
Area of Science:
- Gerontology and Rehabilitation Medicine
- Public Health and Health Services Research
Background:
- Existing exercise rehabilitation programs focus on single long-term conditions (LTCs), potentially inadequately addressing the complex needs of individuals with multiple LTCs (MLTCs).
- The Personalized Exercise-Rehabilitation programme for people with Multiple Long-Term Conditions (PERFORM) was developed to meet the needs of this population.
Purpose of the Study:
- To assess the feasibility and acceptability of the PERFORM intervention for adults with MLTCs.
- To evaluate the trial methods for a future definitive randomized controlled trial (RCT).
Main Methods:
- A parallel, two-group, mixed-methods feasibility RCT involving 60 adults with MLTCs across three UK sites.
- Participants were randomized 2:1 to the PERFORM intervention (8-week supervised exercise and self-care support) plus usual care, or usual care alone.
- Feasibility outcomes included recruitment rates, participant retention, and intervention adherence.
Main Results:
- Target recruitment of 60 participants was achieved within the timeframe.
- Participant retention (EuroQol data) was 76.7%, and intervention adherence was 72.5%.
- High data completion rates (>90%) were observed for most outcome measures.
Conclusions:
- The PERFORM intervention is feasible and acceptable for individuals with MLTCs.
- The findings support the rationale for progressing to a full multicentre RCT to determine clinical and cost-effectiveness.
