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Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...

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CXCR4 PET/CT Predicts Left Ventricular Recovery 8 Months After Acute Myocardial Infarction.

Johanna Diekmann1, Tobias König2, Annika Hess3

  • 1Department of Nuclear Medicine, Hannover Medical School, Hannover, Germany; and diekmann.johanna@mh-hannover.de.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|September 18, 2025
PubMed
Summary

Early imaging of C-X-C motif chemokine receptor 4 (CXCR4) after acute myocardial infarction (AMI) can predict left ventricular remodeling. CXCR4-targeted imaging shows potential for risk stratification and guiding anti-inflammatory therapies in AMI patients.

Keywords:
acute myocardial infarctioncardiac remodelingchemokine receptor 4molecular inflammation imaging

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Area of Science:

  • Cardiovascular Imaging
  • Molecular Imaging
  • Inflammation and Healing

Background:

  • Acute myocardial infarction (AMI) initiates an inflammatory response crucial for healing.
  • C-X-C motif chemokine receptor 4 (CXCR4) plays a role in inflammatory processes.
  • Early prediction of left ventricular (LV) remodeling post-AMI is vital for patient outcomes.

Purpose of the Study:

  • To investigate if early C-X-C motif chemokine receptor 4 (CXCR4) upregulation after AMI predicts left ventricular (LV) remodeling and cardiac function.
  • To assess the potential of CXCR4-targeted molecular imaging for risk stratification in AMI patients.

Main Methods:

  • 49 patients with AMI underwent multimodal cardiac imaging within the first week.
  • Imaging included PET with 68Ga-pentixafor (CXCR4 ligand), myocardial perfusion imaging, and cardiac MRI (CMR).
  • Follow-up CMR was performed after 8.3 ± 4.2 months in 40 patients.

Main Results:

  • Initial PET showed significantly higher CXCR4 expression in the infarct territory compared to blood pool.
  • CXCR4 area correlated with initial and follow-up LV ejection fraction (LV-EF) and initial myocardial injury (LGE).
  • CXCR4 area independently predicted follow-up LV-EF, outperforming baseline LGE extent.

Conclusions:

  • CXCR4-targeted molecular imaging early after AMI has potential to predict ventricular remodeling.
  • This imaging approach may serve as a clinical tool for risk stratification post-AMI.
  • CXCR4 imaging could guide anti-inflammatory therapies in patients recovering from myocardial infarction.