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Severe Immune Checkpoint Inhibitor-associated Gastritis Treated with Steroids and Infliximab
Koki Tanaka1, Toshiyuki Morisawa1, Norio Katayama1
1Department of Gastroenterology and Hepatology, Osaka Saiseikai Nakatsu Hospital, Japan.
Abstract:
This case report describes a 77-year-old man with severe immune-related gastritis after receiving pembrolizumab for lung cancer. Despite initial steroid therapy, he showed no improvement and was diagnosed with steroid refractory immune-related gastritis. Infliximab was added to steroid therapy, resulting in significant clinical and endoscopic improvement. This highlights the importance of early diagnosis of immune-related gastritis by endoscopic and histological findings. Prompt evaluation of steroid efficacy and the early use of infliximab in steroid refractory cases are emphasized for effective management of immune-related gastritis as the indications for immune checkpoint inhibitors have expanded.
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