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Analysis of Clinical Characteristics and Antimicrobial Resistance in 249 Isolates of Streptococcus mitis: a
Jingjing Kuai1, Jianwei Ji1, Ling Xiao1
1Affiliated Hospital 6 of Nantong University, Yancheng Third People's Hospital, Yancheng, China.
Abstract:
Cases of invasive infection caused by Streptococcus mitis have been gradually increasing, but less attention has been paid to its clinical characteristics and drug resistance. This study conducted a single-center retrospective analysis of patients with S. mitis-positive results admitted to a tertiary hospital in Yancheng between January 2020 and December 2024. Data were extracted from case notes and electronic medical records. There were 249 cases of S. mitis detected, with community-acquired infections (44.98%), colonization (46.59%) and hospital-acquired infections (8.43%). Of these, the three departments with the highest detection rates were pediatrics (22.09%), urology (19.68%), and stomatology (11.65%). Primary specimen sources included secretions (23.30%), bronchoalveolar lavage fluid (23.30%), urine (20.48%), and blood (17.67%). In terms of years, the detection rate of S. mitis infection showed an annual increase, while antimicrobial resistance remained stable with a decrease in the year 2024. Our analysis identified associations between patient ages and infection type, specimen source, and antimicrobial resistance profile. Furthermore, we observed distinct resistance patterns across different infection types. These findings underscore the need for enhanced hospital surveillance measures to monitor antimicrobial resistance trends and nosocomial infection patterns associated with S. mitis.
Insights
Invasive infections caused by Streptococcus mitis are rising, particularly in pediatrics and urology. Antimicrobial resistance remained stable, decreasing in 2024, highlighting the need for surveillance.
Area of Science:
- Microbiology
- Infectious Diseases
- Clinical Medicine
Background:
- Invasive infections caused by Streptococcus mitis are increasing globally.
- Limited data exists on the clinical characteristics and antimicrobial resistance patterns of S. mitis infections.
Purpose of the Study:
- To analyze the clinical characteristics and antimicrobial resistance of Streptococcus mitis infections.
- To identify trends in S. mitis detection and resistance over time.
Main Methods:
- Retrospective analysis of 249 S. mitis-positive cases from January 2020 to December 2024.
- Data extraction from electronic medical records and case notes.
- Analysis of infection types, specimen sources, affected departments, and antimicrobial resistance profiles.
Main Results:
- S. mitis was detected in 249 cases, with community-acquired infections (44.98%) and colonization (46.59%) being most common.
- Pediatrics (22.09%), urology (19.68%), and stomatology (11.65%) had the highest detection rates.
- An annual increase in S. mitis detection was observed, with stable antimicrobial resistance, showing a decrease in 2024.
Conclusions:
- S. mitis infections show an increasing trend, with distinct patterns in different departments and specimen sources.
- Antimicrobial resistance patterns vary by infection type, necessitating targeted surveillance.
- Enhanced hospital surveillance is crucial for monitoring antimicrobial resistance and nosocomial infections associated with S. mitis.
