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Updated: Jan 17, 2026

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[Pathogen genome databases development and application in public health].

Z Q Lyu1, Y B Yang1, Y Zhang2

  • 1Shenzhen Center of Disease Control and Prevention, Shenzhen 518055, China.

Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi
|September 18, 2025
PubMed
Summary
This summary is machine-generated.

Genomic databases enhance infectious disease surveillance by improving pathogen identification and tracking. Further development of online databases is crucial for global early warning systems.

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Area of Science:

  • Public Health
  • Genomics
  • Epidemiology

Background:

  • Infectious diseases pose a significant global public health threat, with recent outbreaks straining existing surveillance systems.
  • The rapid development of pathogen genomic databases has transformed disease surveillance over the past two decades.
  • There is an urgent need for more efficient and precise pathogen surveillance networks.

Purpose of the Study:

  • To summarize the development and current status of pathogen genomic databases.
  • To discuss the applications of these databases in public health surveillance.
  • To analyze limitations and challenges in current global health systems and propose future directions for online databases.

Main Methods:

  • Review of the developmental history and current state of pathogen genomic databases.
  • Analysis of database applications in pathogen variation surveillance, identification, and epidemiological tracing.
  • Systematic analysis of limitations and challenges in global health prevention and control.

Main Results:

  • Pathogen genomic databases have significantly improved molecular identification, evolutionary analysis, and transmission tracking.
  • Databases are vital tools for surveillance, identification of novel pathogens, and epidemiological tracing.
  • Current global health systems face limitations that hinder effective infectious disease surveillance and early warning.

Conclusions:

  • Online pathogen databases are essential for enhancing global infectious disease surveillance and early warning systems.
  • Addressing current limitations requires focused development of online pathogen databases.
  • Improved surveillance capabilities are critical for future pandemic preparedness.