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Limb saving with regenerative medicine tactics - a case report.

F Contoli Isoldi, L Vieites, A K De Sá Reis

Acta Chirurgiae Plasticae

|September 18, 2025

Summary

Regenerative medicine, particularly autologous fat grafting (lipografting), shows promise for limb salvage and complex wound repair. This case study highlights successful tissue regeneration and functional recovery after severe hand trauma.

Keywords:

Wound healing fat grafting limb salvage regenerative medicine

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Area of Science:

Regenerative medicine
Tissue engineering
Translational medicine

Background:

Natural tissue regeneration is limited, often resulting in scar tissue instead of full functional restoration.
Regenerative medicine aims to enhance the body's innate healing capacity.
Growth factors and mesenchymal stem cells are key components in promoting tissue repair.

Purpose of the Study:

To evaluate the efficacy of regenerative medicine techniques, specifically lipografting, in a severe limb trauma case.
To demonstrate the potential of lipografting for limb salvage and complex wound healing.
To highlight the application of regenerative medicine in reconstructive surgery.

Main Methods:

A patient with severe hand trauma underwent surgical debridement of necrotic tissue.
Autologous fat grafting (lipografting) was performed to promote tissue regeneration.
Subsequent skin grafting was applied to achieve wound closure and functional recovery.

Main Results:

The patient's limb was successfully salvaged, avoiding amputation.
Lipografting facilitated significant tissue regeneration, evidenced by granulation tissue formation within five weeks.
The applied skin graft integrated successfully, leading to functional recovery of the hand.

Conclusions:

Autologous fat grafting is a viable regenerative medicine strategy for treating complex traumatic injuries and promoting limb salvage.
This case underscores the potential of lipografting in reconstructive surgery for severe wounds.
Further research is warranted to optimize regenerative medicine approaches for complex tissue repair and patient outcomes.