The rural territory of Tarn-et-Garonne faces multiple health challenges, including access to rights and health care services. To meet these needs, the Proxi'Santé 82 program, led by APAS 82 (Association Promotion Autonomie et Santé 82) and funded by the Regional Health Agency ARS Occitanie, highlights key strategies for integrating health into territorial development through on-the-ground experience. Some examples demonstrate the added value of aligning territorial dynamics with health initiatives, such as carrying out activities linked to national cancer screening campaigns. Co-constructing health projects with partners is crucial as it leverages experiential knowledge and helps understand the specific characteristics of the targeted territory. The emergence of the health mediator profession, illustrated in this article, helps reduce territorial inequalities by improving access to information. In conclusion, the creation of the mobile team within a dynamic association, supported by a strong departmental and local partnership network, mediation practices, team mobility, and the use of experiential data has contributed to developing effective and impactful initiatives for the Tarn-et-Garonne region. Through these examples and identified strategies, Proxi'Santé 82 illustrates a proactive approach to health prevention and promotion at both departmental and local levels.