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Updated: Jan 17, 2026

Computed Tomography (CT) Guided Implantation of a Totally Implantable Venous Access Port (TIVAP) through Subclavian Vein
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Computed Tomography (CT) Guided Implantation of a Totally Implantable Venous Access Port (TIVAP) through Subclavian Vein

Published on: January 13, 2026

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Insertion-related complications after central venous catheterization in onco-hematologic children: A prospective

Maria Giuseppina Annetta1, Sonia Mensi2, Tony Christian Morena2

  • 1Department of Anesthesia and Intensive Care, Fondazione Policlinico Universitario "A. Gemelli"-IRCCS, Rome, Italy.

European Journal of Pediatrics
|September 19, 2025
PubMed

Insights

Implementing a comprehensive central venous catheterization bundle significantly reduced complications in pediatric cancer patients. This evidence-based approach enhances safety for children requiring long-term venous access during cancer treatment.

Area of Science:

  • Pediatric Oncology
  • Vascular Access Devices
  • Infection Control

Background:

  • Central venous catheterization in pediatric oncology patients is linked to significant complications.
  • The Italian Group for Long Term Venous Access Devices (GAVeCeLT) developed a seven-component insertion bundle to mitigate these risks.

Purpose of the Study:

  • To evaluate the effectiveness of the GAVeCeLT insertion bundle in reducing complications associated with central venous catheterization in pediatric cancer patients.
  • To prospectively assess the safety and efficacy of this standardized approach.

Main Methods:

  • A prospective study involving 109 pediatric cancer patients requiring central venous catheterization.
  • Implementation of the GAVeCeLT insertion bundle, including ultrasound guidance, aseptic techniques, non-radiological tip confirmation, tunneling, sutureless securement, and exit site protection.
  • Monitoring for immediate, early, and late complications over the study period.

Main Results:

  • 138 central venous access devices were inserted without immediate or early complications.
  • During the first month, 3 catheter-related bloodstream infections (0.7/1000 catheter days) and 9 mechanical complications (6.5%) were recorded.
  • No symptomatic catheter-related thrombosis occurred.

Conclusions:

  • The GAVeCeLT insertion bundle is highly effective in optimizing the safety of central venous catheterization in pediatric cancer patients.
  • This evidence-based bundle significantly reduces the incidence of complications, improving patient outcomes.

Keywords:
Central venous catheterizationChildrenComplicationsOncologyUltrasound

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