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Research Domains Biomedical and Clinical Sciences Oncology and Carcinogenesis Predictive and prognostic markers
Research Domains
Biomedical and Clinical Sciences
Oncology and Carcinogenesis
Predictive and prognostic markers
Multimodal profiling identifies CD4+CXCR5+PD-1- Tfh cells as prognostic and predictive biomarkers in diffuse large B-cell lymphoma

Multimodal profiling identifies CD4+CXCR5+PD-1- Tfh cells as prognostic and predictive biomarkers in diffuse large B-cell lymphoma

Sisi Yu ^1,2, Hao Kong ¹, Huaichao Luo ³, Xingzhong Zhao ⁴, Guanghui Zhu ⁵, Xiuqin Feng ¹, Jie Yang ¹, Xiangji Wu ¹, Yu Dai ¹, Chunwei Wu ¹, James Q Wang ⁶, Dan Cao ⁷, Yang Xu ⁸, Hong Jiang ^1,9, Ping Wang ¹

Sisi Yu ^1,2, Hao Kong ¹, Huaichao Luo ³

¹State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
²Department of Medical Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, Sichuan 610041, China.
³Department of Clinical Laboratory, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, Sichuan 610041, China.
⁴Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China.
⁵West China School of Public Health, West China Fourth Hospital, and State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan 610041, China.
⁶Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Haining, Zhejiang 314400, China.
⁷Division of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
⁸Department of Cardiology of The Second Affiliated Hospital, School of Medicine, Zhejiang University; State Key Laboratory of Transvascular Implantation Devices; Cardiac Function Regeneration Key Laboratory of Zhejiang Province, Hangzhou, Zhejiang 310009, China.
⁹Department of Pancreatic Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

⁰State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

Chinese Medical Journal +

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September 19, 2025

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September 19, 2025

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Summary

No abstract available on PubMed

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

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