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Antibiotic Resistance Patterns of Bacterial Strains in Pediatric Urinary Tract Infections (UTIs)
Mehrnoush Afsharipoor1, Fatemeh Sadat Mir Rashidi1, Fatemeh Dehghan1
1Department of Pediatrics, School of Medicine, Imam Khomeini Hospital, Jiroft University of Medical Sciences. Jiroft, Iran.
Insights
Pediatric urinary tract infections (UTIs) show high rates of antibiotic resistance, with Escherichia coli being the most common pathogen. Urgent surveillance is needed to combat multidrug-resistant bacteria in children.
Area of Science:
- Pediatric infectious diseases
- Microbiology
- Antimicrobial resistance
Background:
- Urinary tract infections (UTIs) are common in children, with increasing antimicrobial resistance complicating treatment.
- Escherichia coli is the predominant uropathogen in pediatric UTIs, exhibiting high resistance rates (50-70%) to common antibiotics like ampicillin, cefixime, and ceftriaxone.
Purpose of the Study:
- To investigate the frequency and antibiotic resistance patterns of bacterial strains isolated from pediatric patients with UTIs in Jiroft city.
Main Methods:
- A cross-sectional study of 113 children under 14 with UTIs from 2022-2023.
- Data collected from medical records and analyzed using SPSS (version 22).
Main Results:
- Escherichia coli was the most frequent pathogen (63.7%), followed by Enterobacter (19.4%).
- Alarming antibiotic resistance was observed, with 100% resistance to ampicillin and cefixime in some strains.
Conclusions:
- High levels of antibiotic resistance in pediatric UTIs necessitate continuous surveillance.
- Understanding regional resistance patterns is crucial for optimizing antibiotic stewardship and combating multidrug-resistant pathogens.
Introduction:
Urinary tract infections (UTIs) are among the most common bacterial infections in children and are increasingly complicated by rising rates of antimicrobial resistance. Recent multicenter studies have reported Escherichia coli as the predominant uropathogen in pediatric UTIs, with resistance rates to commonly used antibiotics such as ampicillin, cefixime, and ceftriaxone ranging from 50% to 70%. This study investigates the frequency and antibiotic resistance of bacterial strains isolated from pediatric patients with UTIs.
Methods:
This cross-sectional descriptive analytical study was conducted on 113 children under 14 years of age with UTIs at Imam Khomeini Hospital (RA) in Jiroft city from 2022 to 2023. The data were collected by referring to the medical records of the hospital and using a checklist from the medical records of the studied patients. The data were analyzed using SPSS (version 22) with both descriptive and inferential statistical methods, applying a significance level of <0.05.
Results:
Escherichia coli was the most frequently isolated pathogen, responsible for 63.7% of cases, followed by Enterobacter at 19.4%.
Discussion:
Notably, alarming levels of antibiotic resistance were observed, with some strains exhibiting complete (100%) resistance to commonly used antibiotics such as ampicillin and cefixime. These findings underscore the necessity for continuous surveillance of uropathogens and their antimicrobial resistance patterns to guide evidence-based therapeutic decision-making.
Conclusion:
A comprehensive understanding of regional epidemiological trends is imperative for clinicians to optimize antibiotic stewardship programs and mitigate the escalating public health challenge of multidrug-resistant pathogens in pediatric urinary tract infections.
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