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Genetic factors for hematological traits in pigs
Jiahong Sun1, Emil Ibragimov1, Peter Karlskov-Mortensen1
1Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark.
Animal Genetics
|September 19, 2025
Summary
This review explores the genetic basis of blood cell traits in pigs, identifying key genetic markers and genes. These findings offer insights into pig health, welfare, and potential applications in both veterinary and human medicine.
Area of Science:
- Genetics
- Veterinary Medicine
- Comparative Genomics
Background:
- Complete blood count with differential is vital for assessing health in humans but underutilized in pigs.
- Understanding the genetic architecture of hematological traits in pigs is crucial for improving animal health and production.
Purpose of the Study:
- To review and synthesize genetic association study data on hematological traits in pigs (Sus scrofa).
- To identify quantitative trait loci (QTL) and candidate genes influencing blood cell parameters in pigs.
- To explore conserved genetic mechanisms between pigs and humans for hematological traits.
Main Methods:
- Systematic review of genetic association studies on porcine hematological traits.
- Compilation and analysis of single nucleotide polymorphisms (SNPs) and QTL data from multiple studies.
- Identification of homologous QTL and candidate genes by comparing porcine and human loci.
Main Results:
- Identified 509 SNPs within 53 high-confidence QTL, with 37 QTL showing homology to human loci.
- Discovered 19 QTL containing plausible candidate genes involved in cytoskeletal formation, hematopoiesis, and immune function.
- Highlighted conserved biological mechanisms regulating hematological traits across species.
Conclusions:
- Provides a foundational understanding of the genetic regulation of blood cell parameters in pigs.
- Suggests potential for translational insights from pig hematology research to human medicine.
- Emphasizes the importance of genetic factors in pig health, welfare, and production traits.
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