Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jan 17, 2026

Optical Scatter Microscopy Based on Two-Dimensional Gabor Filters

Optical Scatter Microscopy Based on Two-Dimensional Gabor Filters

Published on: June 2, 2010

Evaluating a Cellular Microstructure Model Within Apoptotic Cell Death via Diffusion Magnetic Resonance and Long

Daniel Djayakarsana^1,2, Gregory J Czarnota^1,2,3,4, Colleen Bailey¹

¹Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.

NMR in Biomedicine

|September 19, 2025

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Metabolic Assessment in Human Pluripotent Stem Cell-Derived Cerebral Organoids Using HR-MAS NMR Spectroscopy.

NMR in biomedicine·2026

Same author

Evaluation of CNS xenograft brain tumour response to MRI-guided focused ultrasound in combination with radiation therapy.

British journal of cancer·2026

Same author

Early tumour size changes from neoadjuvant chemotherapy as a predictor of pathologic response in breast cancer.

PloS one·2026

Same author

MRI-guided adaptive radiotherapy for high grade glioma (UNITED): a single-centre, single-arm, non-inferiority, phase 2 trial.

The Lancet. Oncology·2026

Same author

Assessing the benefits of using plane wave compounding when estimating backscatter coefficients with an in situ bead as a calibration target.

The Journal of the Acoustical Society of America·2026

Same author

Machine learning for the prediction of three-year survival in locally advanced breast cancer patients receiving neoadjuvant chemotherapy using quantitative ultrasound imaging.

Scientific reports·2026

This summary is machine-generated.

Longer diffusion times in MRI show promise for monitoring cancer treatments that induce apoptosis. This technique can rapidly detect changes in acute myeloid leukemia cells, aiding personalized cancer therapy.

Area of Science:

Biomedical Imaging
Cancer Research
Cell Biology

Background:

Personalized cancer treatment requires rapid response detection.
Inducing apoptosis is a key strategy, leveraging the immune system for cancer cell clearance.
Diffusion MRI shows potential for assessing tumor cellularity changes.

Purpose of the Study:

To investigate the utility of long diffusion times in diffusion-weighted MRI for monitoring apoptosis.
To elucidate water exchange rates in acute myeloid leukemia (AML) cells during induced apoptosis.

Main Methods:

Utilized stimulated echo acquisition mode (STEAM) diffusion imaging with long diffusion times.
Applied a two-pool exchange model to analyze diffusion data.
Induced apoptosis in AML cells using cisplatin.

More Related Videos

Monitoring Neuronal Survival via Longitudinal Fluorescence Microscopy

Monitoring Neuronal Survival via Longitudinal Fluorescence Microscopy

Published on: January 19, 2019

Spot Variation Fluorescence Correlation Spectroscopy for Analysis of Molecular Diffusion at the Plasma Membrane of Living Cells

Spot Variation Fluorescence Correlation Spectroscopy for Analysis of Molecular Diffusion at the Plasma Membrane of Living Cells

Published on: November 12, 2020

Related Experiment Videos

Last Updated: Jan 17, 2026

Optical Scatter Microscopy Based on Two-Dimensional Gabor Filters

Optical Scatter Microscopy Based on Two-Dimensional Gabor Filters

Published on: June 2, 2010

Monitoring Neuronal Survival via Longitudinal Fluorescence Microscopy

Monitoring Neuronal Survival via Longitudinal Fluorescence Microscopy

Published on: January 19, 2019

Spot Variation Fluorescence Correlation Spectroscopy for Analysis of Molecular Diffusion at the Plasma Membrane of Living Cells

Spot Variation Fluorescence Correlation Spectroscopy for Analysis of Molecular Diffusion at the Plasma Membrane of Living Cells

Published on: November 12, 2020

Main Results:

Significant changes observed in key parameters: intracellular fraction (MI) decreased by ~53%, intracellular exchange rate (KIE) increased by ~61%, and cell radius (r) decreased by ~15%.
These alterations correlate with apoptotic changes in AML cells.

Conclusions:

Longer diffusion times in MRI can effectively monitor apoptosis-induced cancer treatment response.
This advanced MRI technique offers a rapid and robust method for assessing treatment efficacy in AML.
The findings support the potential of diffusion MRI for personalized cancer therapy monitoring.