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Relationship between gut microbiota and osteoarthritis: a scientometric analysis.
Zhicheng He1,2, Songrui Xu1,2, Ningning Ma1,2
1Second Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi, China.
Frontiers in Microbiology
|September 19, 2025
Summary
Research on osteoarthritis and gut microbiota is growing. Targeting gut microbiota shows promise for osteoarthritis prevention and management.
Area of Science:
- Bibliometric analysis of osteoarthritis (OA) and gut microbiota (GM) research.
- Exploration of the relationship between gut microbiota and osteoarthritis.
- Analysis of research trends and development in OA and GM.
Background:
- Osteoarthritis (OA) is a degenerative joint disease with complex etiologies.
- Emerging evidence suggests a role for gut microbiota (GM) in OA pathogenesis.
- Understanding the research landscape of OA and GM is crucial for advancing the field.
Purpose of the Study:
- To visualize and analyze the literature on osteoarthritis and gut microbiota from 2011-2024.
- To identify current research status and development trends in the OA-GM field.
- To map the global research output, key institutions, and influential authors.
Main Methods:
- Bibliometric analysis using Web of Science Core Collection (2011-2024).
- Inclusion criteria: articles on "osteoarthritis" and "gut microbiota."
- Analysis of publication output, country, institution, author, keyword, and journal distribution using Excel and CiteSpace.
Main Results:
- 192 articles identified, showing a consistent growth trend in publications.
- China and the United States lead in publication output and citation impact.
- Key research areas include knee osteoarthritis, inflammation, and rheumatoid arthritis, with gut microbiota and gut microbiome as prominent keywords.
Conclusions:
- Research on osteoarthritis and gut microbiota is increasing globally.
- Targeting gut microbiota modulation presents a promising therapeutic strategy for OA.
- Potential clinical applications for OA prevention and management through GM modulation.
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