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Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis
Published on: July 18, 2017
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Emphysematous pyelonephritis: eight case reports and literature review
Du Jiang1, Yang Taoyu2, Wu Tao1
1Department of Urology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Frontiers in Medicine
|September 19, 2025
Summary
Emphysematous pyelonephritis (EPN) treatment requires aggressive antimicrobial therapy and tailored surgical drainage. Appropriate management significantly improves patient prognosis by reducing recurrence, nephrectomy, and mortality rates.
Area of Science:
- Nephrology
- Infectious Diseases
- Urology
Background:
- Emphysematous pyelonephritis (EPN) is a severe necrotizing infection of the renal pelvis.
- Patients often present with complex comorbidities including diabetes, urolithiasis, and chronic renal failure.
Purpose of the Study:
- To summarize the diagnosis and treatment strategies for emphysematous pyelonephritis (EPN).
- To analyze clinical data and compare outcomes with existing literature.
Main Methods:
- Retrospective analysis of eight EPN patients diagnosed between January 2017 and June 2023.
- Review of medical records, including comorbidities, treatment interventions (antimicrobials, surgical drainage), and follow-up data.
Main Results:
- Eight patients (3 male, 5 female; mean age 49.38 years) were included.
- Common complications included sepsis, emphysematous cystitis, chronic renal failure, diabetes, and urolithiasis.
- All patients received antibiotics and tailored drainage procedures; all recovered without recurrence.
Conclusions:
- EPN patients often have severe underlying conditions.
- Appropriate surgical drainage is crucial for reducing infection recurrence, nephrectomy rates, and mortality.
- Effective management improves patient prognosis.
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