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Related Experiment Video

Updated: Jan 17, 2026

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

Published on: November 21, 2025

Standard Versus Enhanced Measurement-Based Care Effectiveness for Depression (EMBED): Protocol for a Cluster

Raymond W Lam¹, Erin E Michalak¹, Jill K Murphy²

¹Psychiatry, University of British Columbia, Vancouver, CAN.

|September 19, 2025

Summary

This summary is machine-generated.

Enhanced measurement-based care (eMBC) using WeChat shows promise for improving depression treatment outcomes. This approach may overcome barriers to standard care, benefiting patients in China and globally.

Keywords:

assessment cluster trial depression implementation measurement-based care mixed-methods mobile health randomized scales wechat

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Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

Area of Science:

Mental Health Research
Digital Health Implementation
Clinical Trial Design

Background:

Measurement-based care (MBC) improves outcomes for major depressive disorder (MDD) but faces implementation barriers.
Enhanced MBC (eMBC) utilizing mobile apps and WeChat may address these challenges.
eMBC integrates patient outcome tracking and self-management support.

Purpose of the Study:

To compare the implementation and clinical effectiveness of eMBC via WeChat against standard MBC.
To evaluate eMBC's impact on patient outcomes and treatment adherence.
To explore contextual factors influencing eMBC implementation through qualitative analysis.

Main Methods:

A hybrid implementation-effectiveness cluster randomized trial (RCT) in 12 Shanghai mental health centers.
Two arms: standard MBC (paper-pencil) vs. eMBC (WeChat mini-program with lay coach support).
Six-month follow-up with 1200 patients and 240 physicians; mixed-methods analysis.

Main Results:

Primary implementation outcome: patient PHQ-9 score recording at six months.
Primary clinical outcome: clinical remission (PHQ-9 ≤ 4) at six months.
Secondary outcomes include medication adherence, doctor-patient alliance, and cost-benefit analysis.

Conclusions:

This trial will provide evidence on the effectiveness of eMBC with WeChat for depression treatment.
Findings will guide the broader implementation of eMBC in China and internationally.
eMBC has the potential to enhance mental healthcare delivery through digital tools.