Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

2.3K
Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
2.3K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.0K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.0K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.6K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systemic regeneration medicines for muscular dystrophy: progress and challenges in pro-regenerative drug development.

Cell regeneration (London, England)·2026
Same author

DMD-Null mice exhibit severe muscle weakness, impaired regeneration, and deficient satellite cell function.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Dystrophin-gene mutation location influences severity of electroretinogram defects in mouse models of Duchenne muscular dystrophy.

BMC medicine·2026
Same author

RNA Therapeutics for Duchenne Muscular Dystrophy: Exon Skipping, RNA Editing, and Translational Insights from Genome-Edited Microminipig Models.

International journal of molecular sciences·2026
Same author

A Novel Dysferlin-Binding Kinase CK2α Promotes Plasma Membrane Repair in Dysferlinopathy.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

Prostaglandin E2 receptor EP2 is indispensable for maintenance of skeletal muscle stem cells.

Stem cells (Dayton, Ohio)·2026

Related Experiment Video

Updated: Jan 17, 2026

Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice
08:13

Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice

Published on: April 10, 2019

6.4K

Stem/progenitor cell-based therapy for Duchenne muscular dystrophy.

Tsukasa Tominari1, Chaitra Sathyaprakash1, Yoshitsugu Aoki1

  • 1Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.

Frontiers in Cell and Developmental Biology
|September 19, 2025
PubMed
Summary
This summary is machine-generated.

Duchenne muscular dystrophy (DMD) therapies face challenges in muscle regeneration. Stem cell therapies show promise for DMD, focusing on cell pre-conditioning and niche treatment for better integration and improved outcomes.

Keywords:
cardiac muscleduchenne muscular dystrophy (DMD)dystrophinskeletal musclestem cell therapies

More Related Videos

CRISPR/Cas9 Technology in Restoring Dystrophin Expression in iPSC-Derived Muscle Progenitors
07:44

CRISPR/Cas9 Technology in Restoring Dystrophin Expression in iPSC-Derived Muscle Progenitors

Published on: September 14, 2019

8.8K
Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration
10:03

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration

Published on: January 20, 2014

10.1K

Related Experiment Videos

Last Updated: Jan 17, 2026

Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice
08:13

Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice

Published on: April 10, 2019

6.4K
CRISPR/Cas9 Technology in Restoring Dystrophin Expression in iPSC-Derived Muscle Progenitors
07:44

CRISPR/Cas9 Technology in Restoring Dystrophin Expression in iPSC-Derived Muscle Progenitors

Published on: September 14, 2019

8.8K
Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration
10:03

Transplantation of Induced Pluripotent Stem Cell-derived Mesoangioblast-like Myogenic Progenitors in Mouse Models of Muscle Regeneration

Published on: January 20, 2014

10.1K

Area of Science:

  • Regenerative Medicine
  • Molecular Biology
  • Genetics

Background:

  • Duchenne muscular dystrophy (DMD) is a genetic disorder characterized by the loss of dystrophin, leading to progressive muscle wasting and cardiac complications.
  • Current molecular therapies for DMD show limited success in promoting tissue regeneration and reducing fibrosis.
  • Stem/progenitor cell-based therapy presents a promising avenue for DMD treatment, but transplantation protocols and cell pre-treatments require optimization.

Purpose of the Study:

  • To review the challenges hindering successful muscle tissue regeneration in DMD.
  • To summarize recent advancements in stem/progenitor cell-based therapies for DMD.
  • To highlight the importance of cell pre-conditioning and disease niche treatment for improved therapeutic outcomes.

Main Methods:

  • Review of existing literature on stem/progenitor cell therapies for Duchenne muscular dystrophy.
  • Analysis of different cell types studied for DMD treatment, including myogenic stem/progenitor cells, mesenchymal stem cells (MSCs), and induced pluripotent stem cells (iPSCs).
  • Focus on pre-conditioning strategies and disease niche modification for enhanced cell integration.

Main Results:

  • Myogenic stem/progenitor cells aim to restore myofiber number and dystrophin expression in DMD muscles.
  • Mesenchymal stem cells (MSCs) exhibit immunosuppressive properties and may complement gene therapies for DMD.
  • Successful DMD muscle regeneration requires overcoming specific challenges related to cell transplantation and the disease microenvironment.

Conclusions:

  • Stem/progenitor cell-based therapies offer a potential strategy for muscle regeneration in DMD patients.
  • Optimizing cell pre-conditioning and addressing the DMD disease niche are critical for successful therapeutic integration.
  • Further research is needed to refine these approaches for effective DMD treatment.