Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.8K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.8K
Hematopoiesis01:21

Hematopoiesis

8.7K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
8.7K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

4.0K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.0K
Lineage Commitment01:21

Lineage Commitment

4.1K
Commitment is the  process whereby stem cells:
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expanded Allelic Diversity of Non-Classical HLA Class I and MIC Loci Identified Using Full-Gene Hybrid Capture-Based Next-Generation Sequencing.

HLA·2026
Same author

Population-agnostic real-time molecular mismatch estimation using rSSO-defined HLA allele strings: minimal impact of allelic discordance with NGS.

Frontiers in immunology·2026
Same author

Non-HLA antibody trajectories may predict kidney transplant outcomes.

Frontiers in immunology·2026
Same author

Functional dynamics between resident transcriptionally active microbes (TAMs) and host genes underlie Dengue severity.

PLoS neglected tropical diseases·2025
Same author

Genomic insights into bacteriophages: a new frontier in AMR detection and phage therapy.

Briefings in functional genomics·2025
Same author

Editorial: Advancements in hematopoietic stem cell proliferation and self-renewal maintenance.

Frontiers in cell and developmental biology·2025

Related Experiment Video

Updated: Jan 17, 2026

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
09:34

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

7.1K

Unlocking hematopoietic stem cell potential: integrative computational approaches for genomic and transcriptomic

Pawan Kumar Raghav1, Basudha Banerjee2, Rajni Chadha2

  • 1Immunogenetics and Transplantation Laboratory, Department of Surgery, University of California San Francisco, San Francisco, CA, United States.

Frontiers in Cell and Developmental Biology
|September 19, 2025
PubMed
Summary

Computational tools are revolutionizing hematopoietic stem cell (HSC) research by enabling detailed analysis of cellular heterogeneity and gene regulatory networks (GRN). This advances understanding of stem cell biology for improved therapies.

Keywords:
HSC transplantationHematopoietic stem cells (HSCs)computational biologydifferentiationregenerative medicineself-renewalsingle-cell RNA sequencing (scRNA-Seq)stem cell therapy

More Related Videos

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

3.0K
A Computational Pipeline for Intergenic/Intragenic Enhancer RNA Quantification in Mouse Embryonic Stem Cells
06:02

A Computational Pipeline for Intergenic/Intragenic Enhancer RNA Quantification in Mouse Embryonic Stem Cells

Published on: October 28, 2025

440

Related Experiment Videos

Last Updated: Jan 17, 2026

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
09:34

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

7.1K
Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
11:36

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

3.0K
A Computational Pipeline for Intergenic/Intragenic Enhancer RNA Quantification in Mouse Embryonic Stem Cells
06:02

A Computational Pipeline for Intergenic/Intragenic Enhancer RNA Quantification in Mouse Embryonic Stem Cells

Published on: October 28, 2025

440

Area of Science:

  • Hematology
  • Stem Cell Biology
  • Computational Biology

Background:

  • Hematopoietic stem cells (HSCs) are crucial for lifelong blood production but are challenging to isolate and characterize due to cellular heterogeneity.
  • Understanding HSC transcriptional and epigenetic regulation is key to unlocking their therapeutic potential.

Purpose of the Study:

  • To review the synergistic role of computational tools in deciphering HSC biology.
  • To highlight advances in resolving HSC heterogeneity and reconstructing gene regulatory networks (GRN).

Main Methods:

  • Single-cell RNA sequencing (scRNA-seq) for transcriptional state analysis.
  • Chromatin immunoprecipitation sequencing (ChIP-seq) for epigenetic profiling.
  • Network inference algorithms and machine learning for GRN reconstruction and data integration.

Main Results:

  • Computational approaches enable high-resolution analysis of HSC transcriptional states and lineage trajectories.
  • Multi-omics data integration reveals epigenetic and transcriptional mechanisms driving stem cell fate.
  • Machine learning models identify novel enhancers, transcription factors, and potential therapeutic targets.

Conclusions:

  • Computational biology tools are essential for understanding complex HSC heterogeneity and function.
  • These advances hold significant promise for developing novel stem cell therapies and precision treatments for hematologic disorders.