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Updated: Jan 17, 2026

Bacteriophage Effectiveness for Biocontrol of Foodborne Pathogens Evaluated via High-Throughput Settings
Published on: August 19, 2021
Next-generation antimicrobials: A review of phage lysins as precision weapons against drug-resistant pathogens
Xinge Cui1, Luwei Chai1, Yongkang Zhang1
1College of Life Sciences, Chongqing Normal University, Chongqing, P. R. China.
Abstract:
The escalating misuse of antibiotics has precipitated a dramatic rise in bacterial drug resistance, rendering conventional therapies increasingly ineffective. In this post-antibiotic era, phage lysins have emerged as a novel class of antimicrobial agents, attracting significant attention for their precise targeting of drug-resistant pathogens. Despite promising preclinical results - highlighting their rapid bactericidal efficacy and synergistic potential with other antimicrobials - the clinical translation of lysins remains limited by unresolved challenges related to efficacy, safety, pharmacokinetics, and dosing optimization. This review provides a comprehensive overview of lysin research advancements, discusses diverse application strategies, and critically evaluates therapeutic outcomes from animal models and early clinical trials. Additionally, it addresses the key obstacles impeding lysin development and proposes practical solutions and future research directions to unlock the full clinical potential of this innovative antimicrobial strategy.
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