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Updated: Jan 17, 2026
Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
Published on: October 28, 2022
[Expression of Concern] PirB restricts neuronal regeneration in developing rat brain following hypoxia‑ischemia
Hua Wang1, Ying Xiong1, Dezhi Mu1
1Department of Pediatrics, West China Second University Hospital, Sichuan University, Sichuan, Chengdu 610041, P.R. China.
Abstract:
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that, regarding the immunofluorescence images shown in Fig. 3, the 'HIBD' panel appeared to share an overlapping section of data with the adjoining 'HIBD+anti PirB' panel, albeit the data held in common appeared to have been vertically stretched in the latter panel. The authors were contacted by the Editorial Office to offer an explanation for this apparent anomaly in the presentation of the data in this paper; however, up to this time, no response from them has been forthcoming. Owing to the fact that the Editorial Office has been made aware of potential issues surrounding the scientific integrity of this paper, we are issuing an Expression of Concern to notify readers of this potential problem while the Editorial Office continues to investigate this matter further. [Molecular Medicine Reports 6: 339‑344, 2012; DOI: 10.3892/mmr.2012.907].
Insights
An expression of concern is issued regarding potential data anomalies in immunofluorescence images. The editorial office is investigating scientific integrity issues after a reader noted overlapping and stretched data in Fig. 3.
Area of Science:
- Immunology
- Cell Biology
- Molecular Medicine
Background:
- A published paper in Molecular Medicine Reports presented immunofluorescence images.
- Concerns were raised regarding the presentation of data in Fig. 3.
Purpose of the Study:
- To address potential scientific integrity issues identified in a published study.
- To inform readers about an ongoing investigation into data presentation anomalies.
Main Methods:
- Review of immunofluorescence images (Fig. 3) from the published paper.
- Contacting authors for clarification on data presentation.
Main Results:
- An apparent overlap and vertical stretching of data between 'HIBD' and 'HIBD+anti PirB' panels in Fig. 3 were observed.
- Authors have not yet provided a response to the editorial office's inquiry.
Conclusions:
- An Expression of Concern has been issued due to potential issues with scientific integrity.
- The editorial office is continuing its investigation into the matter.
