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Updated: Jan 17, 2026
Layer-by-layer Synthesis and Transfer of Freestanding Conjugated Microporous Polymer Nanomembranes
Published on: December 15, 2015
Solvation-Layer Mediated Interfacial Assembly for Surface Topological Engineering of Mesoporous Microcarriers
Enyun Xing1, Yan Yu1, Hongyue Yu1
1Department of Chemistry, Shanghai Stomatological Hospital & School of Stomatology, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, China.
Researchers developed a new method to engineer surfaces of drug carriers, enhancing their interaction with tissues. This topological engineering improves oral drug delivery and therapeutic effectiveness, particularly for gastrointestinal applications.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Surface topological engineering is crucial for advanced drug delivery systems.
- Current methods are limited by substrate properties, necessitating a universal approach.
- Tailoring surface topography optimizes biointerface interactions for enhanced drug delivery.
Purpose of the Study:
- To develop a universal strategy for controlled topological modification of diverse carrier materials.
- To engineer well-defined surface topographies for optimized biointerface interactions.
- To demonstrate enhanced drug delivery and therapeutic performance using the engineered carriers.
Main Methods:
- Developed a solvation-layer mediated interfacial assembly kinetics strategy.
- Achieved uniform growth of periodic mesoporous organosilica (PMO) "hooks" on various substrates (carbon nanotubes, graphene oxide, mesoporous silica microspheres).
- Engineered tunable submicron dimensions (length: 30-200 nm; width: 70-200 nm) for the PMO hooks.
Main Results:
- Created hierarchical surface architectures with significantly enhanced interfacial interactions with mucosal tissues.
- Demonstrated successful coloading of platinum nanoparticles and curcumin onto mesoporous silica microsphere@PMO carriers.
- Achieved prolonged gastrointestinal retention and improved therapeutic performance in a gastric ulcer model.
Conclusions:
- The developed strategy offers a versatile and substrate-adaptive approach for engineering topologically enhanced mesoporous carriers.
- The findings provide valuable insights into structure-function relationships at biological interfaces.
- This work advances the development of efficient oral drug delivery platforms.
