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Updated: Jan 17, 2026
A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
Published on: June 20, 2017
Posttraumatic Stress, Illness Perception, Concussion Symptoms, and Quality of Life Following Mild Traumatic Brain
Background:
Working-age individuals with mild traumatic brain injury (mTBI) often experience persistent postconcussion symptoms (PCSs) that significantly impair their quality of life (QoL). Posttraumatic stress disorder (PTSD) may act as a psychological mechanism linking PCSs to a poorer QoL, whereas illness perception may influence the extent to which PCSs lead to PTSD; these relationships have not been tested. Establishing this moderated mediation pathway is critical for identifying patients at a heightened psychological risk and informing early intervention strategies to optimize postacute rehabilitation outcomes.
Objective:
This study examined the mediating role of PTSD in the relationship between PCSs and QoL, as well as the moderating effect of illness perception on these associations.
Methods:
A longitudinal study was conducted among 120 working-age individuals with mTBI in Indonesia. PCSs and illness perception were assessed at discharge, PTSD was measured at 1 month, and QoL was measured at 3 months postdischarge. A moderated mediation analysis was performed using Hayes' macro, PROCESS Model 7.
Results:
PCSs at discharge were associated with poorer QoL at 3 months, with PTSD fully mediating this relationship. Illness perception moderated the effect of PCSs on PTSD, with more negative perceptions intensifying symptoms. The indirect effect of PCSs on QoL through PTSD was stronger among individuals prone to negative illness perception.
Discussion:
PTSD plays a critical role in mediating the relationship between PCSs and QoL, whereas negative illness perception further amplifies this indirect effect, leading to a poorer QoL 3 months postinjury. These findings confirm the presence of a moderated mediation pathway, highlighting the need for early psychological screening and targeted interventions that address both PTSD and negative illness perception. Integrating these strategies into postacute rehabilitation may improve long-term recovery outcomes in working-age individuals with mTBI.
