Gait Analysis in Rett Syndrome: Integrating Linear and Nonlinear Techniques

Rett syndrome is a rare neurodevelopmental disorder that significantly impairs bipedal postural control and walking ability. This study quantifies the gait characteristics of 22 females with Rett syndrome (divided into 3 age groups) and compares them with age-matched neurotypical females. Bilateral sagittal plane joint angles of the hip, knee, and ankle were analyzed. Measures included joint range of motion, stride time, peak angular velocity, angle-angle diagrams, phase portrait areas, and asymmetries. Results revealed reduced joint range of motion and angular velocity in individuals with Rett syndrome, as well as greater asymmetries in gait parameters reflecting disruptions in bilateral coordination. Phase portraits and angle-angle diagrams indicated preserved coordination in proximal joints but greater variability at the ankle. Ankle movement in individuals with Rett syndrome aged 9-14 years showed a closer resemblance to Controls. These findings identify underlying lower limb motion patterns that contribute to gait deficits in Rett syndrome, guiding future targeted interventions to improve their mobility.