Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

4.0K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
4.0K
Infertility in Males01:23

Infertility in Males

528
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
528

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Germline CDK12 variants in aggressive prostate cancer.

Cancer discovery·2026
Same author

A Multimodal Artificial Intelligence Model to Guide Use of Whole-Pelvic Radiation Therapy in Patients with Localized Prostate Cancer: Exploratory Analysis of RTOG 9413.

Cancers·2026
Same author

The biology of hypomorphic TP53 variants and implications for clinical management.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

The Influence of Social Media Messaging on Human Papillomavirus Vaccine Attitudes and Confidence Among Adolescent Males: Group Discussion Study.

JMIR cancer·2026
Same author

Phase 1b trial of Bavdegalutamide (ARV-110) in combination with Abiraterone for metastatic prostate cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

A quantitative framework to assess the potential of earlier cancer detection to improve cancer survival.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2026

Related Experiment Video

Updated: Jan 17, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

17.1K

Patient-Reported Outcomes From Males Regarding Germline Testing for Prostate Cancer: Results From the PROGRESS

Stacy Loeb1, Scott W Keith2,3, Laura Gross4

  • 1Department of Urology and Population Health, New York University Langone Health and Manhattan Veterans Affairs, New York, NY.

JCO Precision Oncology
|September 19, 2025
PubMed
Summary
This summary is machine-generated.

Patient-reported outcomes (PROs) from the PROGRESS registry show that prostate cancer (PCA) germline testing (GT) satisfaction is highest with phone counseling. Understanding these PROs can improve the patient experience with PCA genetic testing.

More Related Videos

Retzius-Sparing Robot-Assisted Radical Prostatectomy
12:10

Retzius-Sparing Robot-Assisted Radical Prostatectomy

Published on: May 19, 2022

9.0K
Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking
07:34

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Published on: November 17, 2023

1.2K

Related Experiment Videos

Last Updated: Jan 17, 2026

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

17.1K
Retzius-Sparing Robot-Assisted Radical Prostatectomy
12:10

Retzius-Sparing Robot-Assisted Radical Prostatectomy

Published on: May 19, 2022

9.0K
Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking
07:34

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Published on: November 17, 2023

1.2K

Area of Science:

  • Oncology
  • Genetics
  • Patient-Reported Outcomes

Background:

  • Germline testing (GT) for prostate cancer (PCA) is crucial for precision therapy, cancer screening, and assessing hereditary risk.
  • Studying patient-reported outcomes (PROs) is essential for developing patient-centered PCA GT strategies.

Purpose of the Study:

  • To analyze patient-reported outcomes (PROs) from the PROGRESS registry among males undergoing PCA germline testing (GT).
  • To identify factors influencing patient satisfaction, decisional conflict, and perceived benefits of PCA GT.

Main Methods:

  • The PROGRESS registry collected data from English-speaking males over 18 with prior/current PCA GT via online surveys.
  • Data included demographics, PCA and family cancer history, genetics care delivery, satisfaction, decisional conflict, knowledge, and attitudes.
  • Multiple linear regression was used to analyze relationships between participant characteristics and PROs (α = .05).

Main Results:

  • Analyses included 414 participants; 27.9% had positive genetic results.
  • Highest satisfaction was associated with pretest counseling by phone or discussion with a doctor.
  • Males with mutations reported higher perceived benefits and importance of GT; Asian Americans reported lower satisfaction and higher decisional conflict.

Conclusions:

  • The PROGRESS registry provides the first comprehensive report on PROs for males undergoing PCA GT.
  • Findings offer insights into improving patient experience and maximizing the benefits of PCA germline testing.