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Reprogramming the glycocalyx: Advances in glycoengineering for immunomodulation and regenerative medicine

Md Mohosin Rana1, Peyman Malek Mohammadi Nouri1, Seyed Hassan Hosseini2

  • 1Centre for Blood Research and Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada.

Biomaterials
|September 19, 2025
PubMed
Summary

Cell surface glycoengineering precisely modifies the cell membrane and glycocalyx for enhanced immunomodulation and regenerative therapies. Advanced strategies offer therapeutic potential but require careful control to ensure safety and efficacy.

Keywords:
Biomaterial chemistry and engineeringCell surface modificationEnzymatic glycan editingGlycocalyxGlycoengineeringImmunomodulationMetabolic glycoengineeringRegenerative medicineSynthetic and natural glycopolymers

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