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Membrane interactions between adjacent mucols secretion granules.

M R Neutra, S F Schaeffer

The Journal of Cell Biology

|September 1, 1977

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Goblet cells in primates fuse mucous granules at specific membrane sites. These sites are smooth and protein-poor, suggesting they require further stimulation for release.

Area of Science:

Cell biology
Primate cell structure
Mucosal secretion

Background:

Goblet cells are crucial for mucus secretion in primates.
Understanding the mechanisms of mucous granule fusion is key to comprehending mucus release.

Purpose of the Study:

To investigate the ultrastructure of membrane fusion sites in primate goblet cells.
To characterize the molecular composition of these fusion sites.

Main Methods:

Transmission electron microscopy (TEM) of thin sections.
Freeze-fracture electron microscopy (FSEM) of goblet cell membranes.

Main Results:

Identified extensive pentalaminar fusion sites between adjacent mucous granules in TEM.

Related Experiment Videos

Observed smooth membrane surfaces with few 6-8 nm particles on the E face in FSEM replicas.

Characterized these sites as protein-poor and relatively stable.

Conclusions:

Primate goblet cell mucous granule fusion involves specialized, protein-poor membrane domains.
These stable fusion sites may require additional stimuli to initiate membrane fission and mucus release.