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Motor-cognitive aging: The role of motor cortex and its pathways

Jiaqi Wen1, Zifei Liang2, Chenyang Li2

  • 1Department of Radiology, NYU Grossman School of Medicine, NY, NY 10016, USA; Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China.

Neuroimage
|September 19, 2025
PubMed
Summary

Aging leads to brain changes affecting motor and cognitive function. The corticostriatal tract (CStrT) plays a key role, mediating decline linked to motor cortex (M1) atrophy.

Keywords:
AgingHemodynamicsHuman connectome projectMotor CognitionPrimary motor cortexStructureWhite matter tracts

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