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Updated: Jan 17, 2026

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Deciphering the quantitative relationship between NRF2 and SRXN1 through semi-mechanistic computational modeling.

Raju Prasad Sharma1, Liesanne Loonstra-Wolters1, Bas Ter Braak1

  • 1Division of Cell Systems and Drug Safety, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, Leiden 2333 CC, the Netherlands.

Toxicology
|September 19, 2025
PubMed
Summary

Nuclear factor erythroid 2-related factor 2 (NRF2) activity is modulated by cofactors, influencing antioxidant response element (ARE) gene regulation. This modulation is specific to time, compound, and exposure, impacting cellular homeostasis.

Keywords:
Chemical exposureHepatotoxicityNRF2Nonlinear mixed effect modelingRepeated exposureSRXN1

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