EANS-EANO guidelines on the extent of resection in gliomas

Area of Science:

• Neurosurgery
• Neuro-oncology
• Clinical Practice Guidelines

Background:

• Optimizing neurosurgical resection of gliomas is crucial but lacks sufficient evidence for personalized treatment.
• Current personalized treatment decisions for glioma surgery have moderate evidence levels.

Purpose of the Study:

• To provide interdisciplinary guidance on the extent of resection (EOR) in glioma surgery.
• To assess data on EOR in gliomas and evaluate evidence levels.
• To compose evidence-based recommendations for glioma resection.

Main Methods:

• A joint task force by the European Association for Neurosurgical Societies (EANS) and the European Association of Neuro-Oncology (EANO) was established.
• The task force assessed existing data on EOR in gliomas.
• Recommendations were formulated based on evaluated evidence levels (classes I-IV).

Main Results:

• Recommendations were developed for various glioma types, including newly diagnosed and recurrent glioblastomas, IDH-mutant gliomas, ependymomas, and WHO CNS grade 1 tumors.
• The extent of resection (EOR) is routinely determined by postoperative MRI.
• EOR impacts survival, epilepsy, neurocognition, quality of life, neurological status, and treatment planning.

Conclusions:

• The joint EANS and EANO task force successfully provided interdisciplinary guidance on EOR in glioma surgery.
• The recommendations aim to enhance personalized treatment decisions for glioma patients.
• This collaborative effort establishes a foundation for evidence-based glioma resection strategies.